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frontal lobes (Berlyne) In the patients with the alcoholic Korsakoff syndrome studied by M Victor and RD Adams, so-called fantastic confabulation was observed mainly in the initial phase of the illness, in which it could be related to a state of profound general confusion; momentary confabulation came later, in the convalescent stage In the chronic, stable stage of the illness, confabulation was rarely elicitable irrespective of how broadly this symptom was de ned Neuropsychology of Memory It is noteworthy that memory function obeys certain neurologic laws As memory fails, it rst loses its hold on recent events The extent in time of retrograde amnesia is proportionate to the magnitude of the underlying neurologic disorder Early-life memories are better preserved and often have been integrated into habitual responses; nevertheless, with natural aging, there is also a gradual loss of early-life memories In transitory amnesias (eg, concussive head injury), memories are recovered in reverse order: rst the remote and then the more recent The enduring aspect of early-life memories in contrast to more recently experienced and learned material, a restatement of Ribot s law, is apparent in both normal adults and in demented patients As quoted by Kopelman, Ribot in 1882 stated The progressive destruction of memory follows a logical order a law it begins at the most recent recollections which, being rarely repeated and having no permanent associations, represent organization in its feeblest form In the further analysis of the Korsakoff amnesic syndrome, it is necessary to consider the proposition that memory is not a unitary function but takes several forms Thus, a patient with virtually no capacity to learn any newly presented information can still acquire some simple manual and pattern-analyzing skills (eg, mirror reading) Moreover, having acquired these skills, the patient may have no memory of the circumstances in which they were acquired (implicit memory) The learning of simple mechanical skills has been referred to as procedural memory, in distinction to learning new data-based information, referred to as nonprocedural or declarative memory Cohen and Squire have described this dichotomy as knowing how as opposed to knowing that The comments on dementia in this chapter refer, of course, mainly to the declarative, informational type of memory Loss of procedural skill is more in the realm of apraxia Much has also been written in the psychologic literature about two systems of memory referred to as episodic and semantic (Table 21-4) A pervasive problem with these terms is the lack of uniformity in de ning them To Tulving, whose writings on this subject are recommended, the term episodic denotes a memory system for dating personal experiences and their temporal relationships; semantic memory is one s repository of perceptual and factual knowledge, which makes it possible to comprehend language and make inferences This hardly constitutes a novel concept; Korsakoff himself clearly recognized that certain aspects of mental function (among them those now being de ned as semantic memory) remain intact, despite the profound impairment of retentive (episodic) memory As con rmation of the separation of these two functions, Gadian and colleagues have described a group of ve young patients who showed severe impairments of episodic memory with relative preservation of semantic memory, attributable to hypoxic-ischemic injury (bilateral hippocampal atrophy) sustained early in life Here again, the subject matter most relevant to amnesia involves episodic, or autobiographical, memory Damasio has introduced yet another set of terms generic.

LONG-TERM MEMORY IMMEDIATE RECALL WORKING MEMORY EXPLICIT SEMANTIC EPISODIC IMPLICIT PROCEDURAL VISUAL

Short-term recall of objects, plans, names, sequencing Yes Prefrontal cortex, medial temporal lobes, dorsomedial thalamus WernickeKorsakoff syndrome, herpes encephalitis, infarction of hippocampi, dorsomedial thalamus

6:

Agitation, confusion (impaired attention)

Hippocampal infarction, alcoholic Korsakoff syndrome, AD and other CNS degenerative disorders, encephalitis, chronic toxic exposure, tumors

in place of semantic and contextual for episodic To Damasio, generic memory denotes the basic properties of acquired information, such as its class membership and function; he makes the point that in the amnesic syndrome, this component of declarative memory remains intact and only the contextual component is impaired The full signi cance of these categorizations is still being explored The categorical purity of semantic memory is open to question, as is the notion of a strict dichotomy between semantic and episodic memory Most importantly, a separate anatomic basis for these systems of memory has not been clearly established (see below) Further interesting derivative issues regarding the neuropsychology of memory in relation to brain diseases can be found in the review by Kopelman Among these is the degree to which a disparity between retrograde and anterograde memory can be detected in certain diseases that we cannot comment on from clinical experience He also points out subtle distinctions between recall and memory by recognition Neuropsychologists have further subdivided memory and suggested that there are corresponding anatomic regions for speci c categories (Table 21-4) Some of these more complex ones have been alluded to above and others are simply restatements of the act of registration Furthermore, it is not surprising that the participation of certain areas of the brain not primarily involved in memory function, particularly the language and visuospatial areas, are required for the performance of certain memory tasks However, the

notion of a working memory has both clinical and neuropsychologic credibility This term refers to a module of memory that registers the results of a mental operation and holds it temporarily in order to manipulate or use it to perform a subsequent operation; for example, serial arithmetic or alternating a series of letters and numbers It is not clear how this relates to the capacity to register and attend to a task, but there is little question that this is a measurable form of memory Several regions of the brain must be active during tasks of working memory, including the hippocampi and dorsal thalamus, but lesions of the dorsolateral prefrontal cortex most speci cally impair the skill The papers by Goldman-Rakic may be referred to for further discussion of the mechanisms that underlie working memory Finally, there are reasons, based mainly on the neuroanatomic and functional imaging studies discussed below, to view memory for spatial and topographic information in a particular way Certainly the recollection of personally experienced events can be dissociated to some degree from the memory of the topographic arrangement of the scene in which these memories were formed, but often these two elements are inextricably bound in one experience More salient may be a disproportionate degradation of learned topographic and directional information compared to learned semantic material; such a dissociation can be found, but only in relative terms, in patients who have injuries to their right hippocampus, whereas semantic material is dependent more on the left hippocampus (see below)

Split Pie Chart The split pie chart is another favorite of mine In a split pie chart, several data series are displayed per category as a pie segment, and are depicted in proportion to each other For this example, we will go back to the data provider we used previously for the column chart type and have two key figures by year and see what this offers us I like the display of the different sections, and if we add some dimensionality to this, it immediately looks close to being a finished chart The next illustration shows an example of the end result

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The at spot at the top of the model represents the maximum pro t from the position between the two short strike prices This example is hypothetical and based on the settlements for all the options on the day of the capture Placing an iron condor spread with this advantageous a premium is not terribly likely, although it is possible in the right volatility conditions The real bidand-offer process for executing this trade would have a natural spread between the bid and offer for each option which may make the spread premium capture less and the overall risk higher The iron condor can be placed as one order, or you can leg into the spread by creating each of the credit spreads separately In a high-risk market like the S&P, you should not be trading naked on any side of the market unless you have the ability to carry the full risk of the S&P 500 futures contract Be prepared for the full risk of the underlying asset if you are legging into a spread The dif culty with legging is that markets move quickly and could remove any chance of pro tability if the underlying changes price before the trade is covered