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those bers that course longitudinally in the pyramid of the medulla oblongata Of all the ber bundles in the brain, the pyramidal tract has been known for the longest time, the rst accurate description having been given by Turck in 1851 It descends from the cerebral cortex; traverses the subcortical white matter (corona radiata), internal capsule, cerebral peduncle, basis pontis (ventral pons), and pyramid of the upper medulla; decussates in the lower medulla; and continues its caudal course in the lateral funiculus of the spinal cord hence the alternative name corticospinal tract This is the only direct long- ber connection between the cerebral cortex and the spinal cord (Fig 3-2) The indirect pathways through which the cortex in uences spinal motor neurons are the rubrospinal, reticulospinal, vestibulospinal, and tectospinal; these tracts do not run in the pyramid All of these pathways, direct and indirect, are embraced by the term upper motor neuron A major source of confusion about the pyramidal tract stems from the traditional view, formulated at the turn of the century, that it originates entirely from the large motor cells of Betz in the fth layer of the precentral convolution (the primary motor cortex, or area 4 of Brodmann) (Figs 3-3 and 22-1) However, there are only some 25,000 to 35,000 Betz cells, whereas the medullary pyramid contains about 1 million axons (Lassek) The pyramidal tract, therefore, contains many bers that arise from cortical neurons other than Betz cells, particularly in Brodmann s areas 4 and 6 (the frontal cortex immediately rostral to area 4, including the medial portion of the superior frontal gyrus, ie, the supplementary motor area); in the primary somatosensory cortex (Brodmann s areas 3, 1, and 2); and in the superior parietal lobule (areas 5 and 7) Data concerning the origin of the pyramidal tract in humans are scanty, but in the monkey, by counting the pyramidal axons that remained after cortical excisions and long survival periods, Russell and DeMyer found that 40 percent of the descending axons arose in the parietal lobe, 31 percent in motor area 4, and the remaining 29 percent in premotor area 6 Studies of retrograde transport of tracer substance in the monkey have con rmed these ndings Fibers from the motor and premotor cortices (Brodmann s areas 4 and 6, Fig 22-1), supplementary motor cortex, and portions of parietal cortex (areas 1, 3, 5, and 7) converge in the corona radiata and descend through the posterior limb of the internal capsule, basis pedunculi, basis pontis, and medulla As the corticospinal tracts descend in the cerebrum and brainstem, they send collaterals to the striatum, thalamus, red nucleus, cerebellum, and reticular formations Accompanying the corticospinal tracts in the brainstem are the corticobulbar tracts, which are distributed to motor nuclei of the cranial nerves ipsilaterally and contralaterally (Fig 3-2) It has been possible to trace the direct projection of axons of cortical neurons to the trigeminal, facial, ambiguus, and hypoglossal nuclei (Iwatsubo et al) No axons were seen to terminate directly in the oculomotor, trochlear, abducens, or vagal nuclei Insofar as the corticobulbar and corticospinal bers have a similar origin and the motor nuclei of the brainstem are the homologues of the motor neurons of the spinal cord, the term upper motor neurons may suitably be applied to both these systems of bers The corticospinal tracts decussate at the lower end of the medulla, although some of their bers may cross above this level The proportion of crossed and uncrossed bers varies to some extent from one person to another Most textbooks state that 75 to 80 percent of the bers cross and that the remainder descend ipsilaterally, mostly in the uncrossed ventral corticospinal tract In exceptional cases, these tracts cross completely; equally rarely, they remain uncrossed These variations are probably of functional sig-.

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The amnesic (Korsakoff) syndrome may be a manifestation of several neurologic disorders, identi ed by their mode of onset and clinical course, the associated neurologic signs, and ancillary ndings (Table 21-5) Each of the amnesic states listed in Table 21-5 is considered at an appropriate point in subsequent chapters of this book The only exception is the striking syndrome of transient global amnesia, the nature of which is not certain It cannot be included with any assurance with the epilepsies or the cerebrovascular diseases or any other category of disease and is therefore considered here

This was the name applied by Fisher and Adams to a particular type of memory disorder that they observed in more than 20 middle-aged and elderly persons The condition was characterized by an episode of amnesia and bewilderment lasting for several hours The symptoms had their basis in an amnesia for events of the

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I know GS1-128 and also EPC and I worked with barcodes (as part of a project for warehouse management) - those are standards made for the paper mostly.

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