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This has been pondered almost endlessly by physiologists and psychiatrists Parkes has reviewed the main theories body restitution, facilitation of motor function, consolidation of learning and memory and tends to agree with the ungrammatical but unambiguous conclusion of Popper and Eccles that Sleep is a natural repeated unconsciousness that we do not even know the reason for There is no convincing proof, for example, of the popular notion that we stabilize learned material while asleep, nor can one logically entertain the notion that the function of sleep is to produce dreams, at least until the utility and meaning of dreams become known On the basis of plausibility and logic, we favor the simple notion that sleep restores strength and physical and mental energy Regarding neurophysiologic changes during dreaming, Braun and colleagues, who used positron emission tomography (PET) to study REM sleep, observed selective activation of the extrastriate visual cortices and limbic-paralimbic regions, with concomitant attenuation of activity in the primary visual cortex and frontal association areas The relation of these ndings to the nature of dreams is discussed below Based on these and similar studies, several authors have speculated that the suppression of frontal lobe activity during dreaming, at a time when visual association areas and their paralimbic connections are activated, might explain the uncritical acceptance of the bizarre visual content, the disordered temporal relationships, and the heightened emotionality that characterize dreams, as mentioned earlier This would be in keeping with Hobson s expressed view of dreams as a form of delirium (This is an interesting idea and one that we nd appealing, but it explains little, since the nature of delirium is also obscure) As an alternative that links dreams to inherent meaning for the individual, Solms has suggested that activation of frontal dopaminergic systems, the same pathways that participate in most biologic drives, implies that dreams express latent wishes and drives the classic psychoanalytical interpretation expressed by Freud in his book The Interpretation of Dreams We remain skeptical of these views.

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tonic dystrophy; glycogen masses in glycogen storage diseases, rods (nemaline), central cores, aggregates of lipid bodies, and other cytoplasmic changes in certain congenital myopathies; and nuclear and cytoplasmic inclusions (and other changes) that characterize inclusion-body myositis Application of histochemical methods and electron microscopy are the important techniques in the diagnosis of these disorders These are discussed in relation to each of these speci ed diseases in the following chapters Abnormalities of mitochondria Several distinctive abnormalities are readily visualized in muscle biopsies and are virtually diagnostic of an entire class of mitochondrial diseases Light microscopy of frozen sections of muscle stained with the Gomori trichrome stain show the main feature, so-called ragged red bers, which are accumulations of subsarcolemmal mitochondria Disorders of the neuromuscular junctions in which nerve bers and muscle bers appear to be intact Here an abnormality may be revealed by performing the demanding procedure of motor point biopsy (to include the motor end plate), and using electron microscopy and special staining techniques for nerve terminals, cholinesterase, and the outlining of acetylcholine receptors Myasthenia gravis, botulism, Lambert-Eaton syndrome, and myasthenic syndrome with motor end-plate cholinesterase de ciency fall into this category Biopsy is rarely necessary for the diagnosis of these disorders but it has added considerably to our understanding of them

As a rule, the muscle biopsy procedure requires no more than a small cleanly excised block of muscle, 10 to 20 cm, which is prevented from contracting by a clamp or by tying at full length to a tongue depressor As an alternative to the standard surgical technique, percutaneous needle biopsies are now being done routinely in neuromuscular clinics and may be adequate for the diagnosis of certain muscle dystrophies and for their study over time and for a number of other muscle diseases and denervation atrophy Unfortunately, the erratic distribution of lesions in many of the common disorders of muscle lessens the diagnostic yield of all types of biopsy, but in general the needle biopsy is less satisfactory than an open biopsy The study of the muscle biopsy requires special care in removal, transport, and xation techniques These are discussed in detail by Engel

Using the Back to Initial State command (BACK_TO_INITIAL_ITEM_STATE), you can restore a Web item in a Web application to its original state If you use this command with the Web Template dialog box, the initial state is the display that existed when the dialog box was first opened Table 6-9 lists and describes the command parameters in the same sequence that they appear in the command wizard when you insert the command

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