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the bridges that permit the adaptation of organismal needs to the external environment This concept of central nervous system function, rst proposed by Broca, was elaborated by Yakovlev and has been adopted more recently by Mesulam and by Benson Such a model retains to a large degree the cytoarchitectural similarities among areas that serve similar functions (ie, the scheme of Brodmann) and also respects the sequence of maturation (myelination) of connecting pathways proposed by Flechsig (see Fig 28-3) The latter corresponds to the functional development of primary, secondary, and tertiary associative cortical regions In this way, localization may be viewed as the product of genetic patterns of structure, which mature during development, and their synaptic formations, which permit the development of complex circuits during lifelong learning and experience From these remarks it follows that subdivision of the cerebrum into frontal, temporal, parietal, and occipital lobes is somewhat of an anachronism of limited psychophysiologic validity, although, in clinical work, it still serves an important practical purpose as a shorthand way of localizing a lesion Some of these delineations were made long before our rst glimmer of knowledge about the function of the cerebrum Even when the neurohistologists began parceling the neocortex, they found that their areas did not fall neatly within zones bounded by sulci and ssures Therefore, when the terms frontal, parietal, temporal, and occipital are used in the text below, it is mainly to provide the clinician with familiar and manageable anatomic landmarks (see Fig 22-7) Following from the issues expressed above, a comment should be made regarding the study of cortical function by functional imaging techniques [positron emission tomography (PET) and functional magnetic resonance imaging (fMRI)] These extraordinary images reveal the brain regions that are activated during various normal behaviors Some techniques use regional cerebral blood ow, regional oxygen content, or diffusion of water as surrogates for local metabolic brain activity and neuronal activation (see reviews by Gore and by Le Bihan) Invariably, an ensemble of areas, a network of the variety mentioned above, is required to perform even seemingly simple tasks such as recalling a name, visualizing or identifying an object, or carrying out a commanded task The fact that multiple areas of the cortex are entrained may seem at odds with the classic view of lesional neurology in which one localized area is assigned to a particular clinical syndrome (as de ned by a behavioral de cit) The discrepancy is in part one of epistemology in that normal function as re ected in functional images does not equate with abnormal function as exposed by a focal lesion Moreover, it appears from these imaging studies that certain regions of the cortex are necessary to fully conduct particular behaviors, but they are not suf cient for their enactment Restated, a number of ancillary regions appear by functional imaging to participate in these behaviors, but they act in a supplementary way A rough analogy can be made with memory function as described in Chap 21, where hippocampal destruction results in complete amnesia but undoubtedly other areas of the brain participate in normal memory Possibly lesions in these supplementary areas may impair function to a small degree, but these areas are not requisite for the behavior and therefore are not demonstrable in the clinical examination These considerations notwithstanding, there is little doubt that functional imaging provides insights into the co-ordinated interaction of spatially distributed brain regions in normal behavior They also promise to illuminate patterns of diseased brain function and recovery from these processes. barcode generator vb.net download Generate and display barcode on a form in Visual Basic .NET using ...
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