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hemisphere Neurons of layer V (projection efferents) send axons to subcortical structures and the spinal cord Neurons of layer VI project mainly to the thalamus In the macaque brain, each pyramidal neuron in layer V has about 60,000 synapses, and one afferent axon may synapse with dendrites of as many as 5000 neurons; these gures convey some idea of the wealth and complexity of cortical connections These columnar ensembles of neurons, on both the sensory and motor sides, function as the elementary working units of the cortex, in a manner that is most apparent in the motor and sensory activities described in Chaps 3, 8, and 9 Whereas certain regions of the cerebrum are committed to special perceptual, motor, sensory, mnemonic, and linguistic activities, the underlying intricacy of the anatomy and psychophysical

Figure 22-2 A and B Approximate distribution of functional zones on lateral (above) and medial (below) aspects of the cerebral cortex Abbreviations: AA, auditory association cortex; AG, angular gyrus; A1, primary auditory cortex; CG, cingulate cortex; IPL, inferior parietal lobule; IT, inferior temporal gyrus; MA, motor association cortex; MPO, medial parieto-occipital area; MT, middle temporal gyrus; M1, primary motor area; OF, orbitofrontal region; PC, prefrontal cortex; PH, parahippocampal region; PO, parolfactory area; PS, peristriate cortex; RS, retrosplenial area; SA, somatosensory association cortex; SG, supramarginal gyrus; SPL, superior parietal lobule; ST, superior temporal gyrus; S1, primary somatosensory area; TP, temporopolar cortex; VA, visual association cortex; V1, primary visual cortex (Redrawn by permission from Mesulam M-M)

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V 5b 6a1 a 6a2 VI 6b1 b 6b2 Figure 22-3 The basic cytoarchitecture of the cerebral cortex, adapted from Brodmann The six basic cell layers are indicated on the left, and the ber layers on the right (see text) Infrastriate layer Internal band of Baillarger

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mechanisms in each region are just beginning to be envisioned The lateral geniculate-occipital organization in relation to vision and recognition of form, stemming from the work of Hubel and Wiesel, may be taken as an example In area 17, the polar region of the occipital lobe, there are discrete, highly specialized groups of neurons, each of which is activated in a small area of lamina 4 by spots of light or lines and transmitted via particular cells in the lateral geniculate bodies; other groups of adjacent cortical neurons are essential for the perception of color (see also page 404) Preparedness for all types of visual stimulation and recognition of objects, faces, and verbal and mathematical symbols also involves these areas but is integrated with other cortical regions Lying between the main unimodal receptive areas for vision, audition, and somesthetic perception are zones of integration called heteromodal cortices In the latter regions, neurons respond to more than one sensory modality or neurons responsive to one sense are interspersed with neurons responsive to another Cortical-subcortical integrations are re ected in volitional or commanded movements A simple movement of the hand, for example, requires activation of the premotor cortex (also called accessory motor cortex), which projects to the striatum and cerebellum and back to the motor cortex via a complex thalamic circuitry before the direct and indirect corticospinal pathways can activate certain combinations of spinal motor neurons (see Chaps 3 and 4) Interregional connections of the cerebrum are required for all natural sensorimotor functions; moreover, as indicated above, their destruction disinhibits or releases other areas Denny-Brown has referred to the latter as cortical tropisms Or, the cortical areas surrounding a particular region may be damaged and result in a unique de cit that is the result of isolation or disconnection of that region Thus, destruction of the premotor areas, leaving precentral and parietal lobes intact, results in release of sensorimotor automatisms such as groping, grasping, and sucking Parietal lesions result in complex avoidance movements to contactual stimuli Temporal lesions lead to a visually activated reaction to every observed object and its oral exploration, and limbic sexual mechanisms are rendered hyperactive Some of the aforementioned disorders and others known simplistically as disconnection syndromes depend not merely on involvement of certain cortical regions but also on the interruption of inter- and intra-.

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Web items used in our reports We will see in the next chapter that there are some additional commands from other command areas that we will use in our dynamic dashboards Much of the command functionality is consistent with what you learned in this chapter, so you ll be able to easily work through those other commands without requiring much explanation One important takeaway from this chapter is that there is a ton of flexibility in the approach to creating a chart or configuring the parameters of a chart You can work with almost any functional requirements in the WAD to accommodate the business user s needs The chart types discussed in this chapter are taken directly from Excel functionality and are supported by a very slick HTML backend, so you can create these charts using mostly Excel functionality and then display them in the Web The following chapter pulls together everything that we talked about here and in the previous chapters to build a dashboard using the SAP WAD and the BEx Web Analyzer

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An option premium is composed of two values: intrinsic value and extrinsic value Intrinsic value is present in options that are in the money This value is related to the option s strike price and the current price of the underlying instrument A call option has intrinsic value when

19 46 Lateral 10 45 47 11 44 43 22 17 21 38 20 6 8 9 24 32 33 Medial 10 12 11 28 38 36 37 19 18 29 26 27 30 25 35 34 31 23 19 18 4 3 1 2 18 37 19 41 42 40 39 18

Figure 22-4 Four fundamental types of cerebral cortex and their distribution in the cerebrum The primary visual cortex has a preponderance of small neurons, hence it was historically called granular The primary motor cortex, by contrast, has relatively fewer small neurons and was described as agranular (Reproduced with permission from Kandel ER, Schwartz JH, Jessel TM: Principles of Neural Science, 4th ed New York, McGraw-Hill, 2000)

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